![]() ![]() ![]() The most common cause (about 90% of the time) is due to a small tumor of the pituitary gland called a pituitary microadenoma. There can be two causes of the excessive production. This negative feedback loop controls the amount of cortisol produced.Ĭushing’s disease is caused by the adrenal cortex over-producing cortisol. In other words, by producing increasing amounts of cortisol, the cortisol actually turns off more production, keeping things in balance. The production of cortisol, in turn, causes a negative feedback on the pituitary, thus decreasing the amount of ACTH produced. Normally, in response to stressful situations, the pituitary gland produces ACTH that in turn causes the adrenal cortex to produce cortisol. The production of cortisol is regulated by the hypothalamus and pituitary gland. Trying to diagnose and treat animals with this disorder can sometimes be frustrating, but if a clinical approach is taken, it can be much easier and more rewarding.Ĭushing’s disease is caused by a hyperfunctioning adrenal cortex that is producing excessive cortisol. Veterinary Clinic for Low Income Pet Ownersīy Doug Brum, one of the most confusing endocrine disorders is hyperadrenocorticism or Cushing’s disease. ![]() Vet Services Report Cruelty Animal Advocacy Adopt
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